Zhenyuan Song

Zhenyuan Song

Assoicate Professor, Kinesiology and Nutrition

Office Phone



1919 W. Taylor St., 627 AHSB

Mail Code


Office Hours

By appointment


Research Focus:
Investigating the cellular/molecular mechanisms underlying the pathogenesis of metabolic liver diseases, including alcoholic liver disease (ASD) and obesity-associated non-alcoholic fatty liver disease (NAFLD) using both in vitro and in vivo models.

1. HN308: Nutrition Sciences I
2. HN510: Physiological Aspect of Human Nutrition

Selected Grants

NIH-NIAAA, Homocysteine, Adiponectin, and Alcoholic Liver Disease, PI

NIH-NIDDK, Mechanisms of Sensitization to TNF hepatotoxicity in ALD, PI

NIH-NIDDK, Acute pancreatitis and obesity, Co-I (PI: Giamila Fantuzzi)

UIC CCTS, Use of the fast-food diet mouse to model the pathophysiology of NASH., Co-PI

Selected Publications

“Nicotinamide ameliorates palmitate-induced ER stress in hepatocytes via cAMP/PKA/CREB pathway-dependent Sirt1 upregulation”, Biochim Biophys Acta. 1853:2929-36, 2015.

“Rectification of impaired adipose tissue methylation status and lipolytic response contributes to hepatoprotective effect of betaine supplementation in a mouse model of alcoholic liver disease”, The British Journal of Pharmacology 171:4073-86, 2014.

“Nrf2 activation-induced hepatic VLDL receptor overexpression in response to oxidative stress contributes to alcoholic liver disease in mice”, Hepatology. 59:1381-92, 2014.

“Tert-butylhydroquinone (tBHQ) protects hepatocytes against lipotoxicity via inducing autophagy independently of Nrf2 activation”, BBA-Molecular and cell biology of lipids. 1841:22-33, 2014

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