{"id":20740,"date":"2020-05-13T17:27:03","date_gmt":"2020-05-13T17:27:03","guid":{"rendered":"https:\/\/ahs.uic.edu\/inside-ahs\/news-stories\/research-group-led-by-zhenyuan-song-publishes-a-research-paper-in-the-journal-of-hepatology\/"},"modified":"2020-05-13T17:27:03","modified_gmt":"2020-05-13T17:27:03","slug":"research-group-led-by-zhenyuan-song-publishes-a-research-paper-in-the-journal-of-hepatology","status":"publish","type":"news","link":"https:\/\/ahs.uic.edu\/inside-ahs\/news-stories\/research-group-led-by-zhenyuan-song-publishes-a-research-paper-in-the-journal-of-hepatology\/","title":{"rendered":"Research group led by Zhenyuan Song publishes a research paper in the Journal of Hepatology"},"template":"","news_categories":[13],"news_tags":[],"class_list":["post-20740","news","type-news","status-publish","hentry","news_categories-publications"],"acf":{"intro_text_subtitle":"","intro_text_body":"<div class=\"article-header__middle\">\n<p>A research group led by <a href=\"https:\/\/ahs.uic.edu\/kinesiology-nutrition\/directory\/song-zhenyuan-2\/\"><strong>Zhenyuan Song<\/strong><\/a> published a paper titled, &#8220;<a href=\"https:\/\/www.journal-of-hepatology.eu\/article\/S0168-8278(20)30284-1\/pdf\">ER stress-induced upregulation of NNMT contributes to alcohol-related fatty liver development<\/a>&#8221; in the Journal of Hepatology.<\/p>\n<p><strong>Authors:<\/strong><\/p>\n<div class=\"article-header__middle\">\n<div class=\"dropBlock article-header__info\">Qing Song, Yingli Chen, Jun Wang, Liuyi Hao, Chuyi Huang, Alexandra Griffiths, Zhaoli Sun, Zhangxiang Zhou and Zhenyuan Song.<\/div>\n<div class=\"dropBlock article-header__info\"><\/div>\n<\/div>\n<div class=\"article-header__wrapper\">\n<div class=\"article-header__bottom clearfix row\">\n<div class=\"col-md-6 static-md\">\n<div class=\"plum-jbs-theme\">\n<div class=\"PlumX-Popup\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"article-header__dropZone pb-dropzone\"><\/div>\n<p><strong>Highlights<\/strong>:<\/p>\n<div class=\"section-paragraph\">\n<ul class=\"ce-list--remove-bullets\">\n<li class=\"ce-list--remove-bullets__list-item\">Chronic alcohol consumption upregulates NNMT expression and activity in the liver.<\/li>\n<li class=\"ce-list--remove-bullets__list-item\">The activation of the PERK-ATF4 pathway of UPR contributes to alcohol-induced hepatic NNMT upregulation.<\/li>\n<li class=\"ce-list--remove-bullets__list-item\">Adenoviral knockdown of NNMT protects against fatty liver development in response to both ER stress and chronic alcohol exposure.<\/li>\n<li class=\"ce-list--remove-bullets__list-item\">NNMT inhibition enhances cellular NAD <sup>+<\/sup> levels.<\/li>\n<li class=\"ce-list--remove-bullets__list-item\">NNMT knockdown suppresses <em>de novo<\/em> lipogenesis pathway in hepatocytes and the liver.<\/li>\n<\/ul>\n<\/div>\n<h2 class=\"top\"><\/h2>\n<\/div>\n","intro_text_excerpt":"KN researchers collaborated with researchers from University of North Carolina at Chapel Hill and Johns Hopkins University","content_author":"Zhenyuan  Song","content_sticky":false,"intro_text_include_image":false,"intro_text_image":false,"intro_text_image_alt_text":"","intro_text_image_caption":"","intro_text_image_attribution":"","news_include_thumbnail":false,"news_thumbnail_image":false,"news_thumbnail_image_alt_text":""},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/ahs.uic.edu\/inside-ahs\/wp-json\/wp\/v2\/news\/20740","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ahs.uic.edu\/inside-ahs\/wp-json\/wp\/v2\/news"}],"about":[{"href":"https:\/\/ahs.uic.edu\/inside-ahs\/wp-json\/wp\/v2\/types\/news"}],"version-history":[{"count":0,"href":"https:\/\/ahs.uic.edu\/inside-ahs\/wp-json\/wp\/v2\/news\/20740\/revisions"}],"wp:attachment":[{"href":"https:\/\/ahs.uic.edu\/inside-ahs\/wp-json\/wp\/v2\/media?parent=20740"}],"wp:term":[{"taxonomy":"news_categories","embeddable":true,"href":"https:\/\/ahs.uic.edu\/inside-ahs\/wp-json\/wp\/v2\/news_categories?post=20740"},{"taxonomy":"news_tags","embeddable":true,"href":"https:\/\/ahs.uic.edu\/inside-ahs\/wp-json\/wp\/v2\/news_tags?post=20740"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}