Funding Opportunity: Broad Pragmatic Studies PCORI Funding Announcement — Cycle 2 2026
Introduction
This PCORI Funding Announcement invites applications for high-impact patient-centered comparative clinical effectiveness research (CER) projects. For Cycle 2 2026, PCORI is particularly interested in submissions that address the following Special Areas of Emphasis.
- Diabetes Prevention, Care and Treatment: PCORI seeks to fund high-quality, patient-centered CER studies on prevention, care and treatment options for people with diabetes and prediabetes.
- Addressing Obesity: PCORI is interested in supporting high-quality, patient-centered research to study the comparative clinical effectiveness of interventions that address obesity treatment and/or management, including intensive lifestyle interventions, anti-obesity medications, endoscopic procedures and bariatric surgery, as well as combination approaches, as appropriate. Research evaluating a clinically meaningful, objective and obesity-related primary outcome is highly encouraged.
- Management of Urogynecological and Pelvic Pain: PCORI is interested in funding patient-, healthcare-provider- and/or systems-level CER comparing strategies aimed to improve prevention, screening, diagnosis, treatment and management of urogynecological and pelvic pain, including but not limited to urogynecological and pelvic pain experienced during pregnancy and postpartum. The inclusion of at least one validated primary outcome focused on pain is highly encouraged.
- Pain Management for Individuals Living With Sickle Cell Disease: PCORI is interested in funding patient-, healthcare-provider- and/or systems-level CER comparing strategies aimed at improving screening, diagnosis, treatment and management of acute and chronic pain associated with sickle cell disease among children and adults. The inclusion of at least one validated primary outcome focused on pain is highly encouraged.
See more information here.
Please contact Dr. Karen Cielo, Director of Research Development, if you are interested in applying or would like to discuss the opportunity.