Zhenyuan Song
Professor
Kinesiology and Nutrition
Contact
Building & Room:
747 AHSB
Address:
1919 W. Taylor St.
Office Phone:
Email:
CV Download:
About
Research Focus:
Investigating the cellular/molecular mechanisms underlying the pathogenesis of metabolic liver diseases, including alcoholic liver disease (ALD) and obesity-related non-alcoholic fatty liver disease (NAFLD) using both in vitro cell culture and in vivo animal models.
Teachings:
- HN308: Nutrition Sciences I-Macronutrients Metabolism
- HN510: Physiological Aspect of Human Nutrition
- HN594: Cell Metabolism and Molecular Nutrition
Selected Grants
NIH-NIAAA, The Role and Mechanisms of Hepatic Nicotinamide N-Methyltransferase in the Pathogenesis of Alcoholic Liver Disease, PI
NIH-NIDDK, PPARgamma regulated mechanisms in hepatocytes that promote NAFLD, Co-I
Selected Publications
Gut-derived ammonia contributes to alcohol-related fatty liver development via facilitating ethanol metabolism and provoking ATF4-dependent de novo lipogenesis activation. Metabolism 2024
Nicotinamide N-methyltransferase (NNMT) upregulation contributes to palmitate-elicited peroxisome proliferator-activated receptor
(PPAR)γ transactivation in hepatocytes. AJP-Cell Physiology 2023
mTORC1 inhibition uncouples lipolysis and thermogenesis in white adipose tissue to contribute to alcoholic liver disease. Hepatology Communications 2023
ATF4 activation promotes hepatic mitochondrial dysfunction by repressing NRF1-TFAM signaling in alcoholic steatohepatitis. Gut 2021