Professor, Kinesiology and Nutrition
1919 W. Taylor St., 627 AHSB
Investigating the cellular/molecular mechanisms underlying the pathogenesis of metabolic liver diseases, including alcoholic liver disease (ALD) and obesity-related non-alcoholic fatty liver disease (NAFLD) using both in vitro cell culture and in vivo animal models.
1. HN308: Nutrition Sciences I-Macronutrients Metabolism
2. HN510: Physiological Aspect of Human Nutrition
NIH-NIAAA, Central nervous system-adipose tissue axis in the pathogenesis of alcoholic liver disease, PI
NIH-NIAAA, The pathological role of nicotinamide N-methyltransferase in alcoholic liver disease, PI
NIH-NIDDK, Alternate day fasting combined with exercise for the treatment of NAFLD, Co-I (PI: Dr. Krista Varady)
NIH-NIDDK, Acute pancreatitis and obesity, Co-I (PI: Dr. Giamila Fantuzzi)
“ER stress-mediated liver NNMT upregulation via the PERK-ATF4 pathway activation contributes to alcoholic fatty liver development. ”, Journal of Hepatology 73: 783-793, 2020.
“Inositol requiring enzyme 1alpha (IRE1alpha) connects palmitate-induced mTOR activation and lipotoxicity in hepatocytes.”, American Journal of Physiololgy-Cell Physiology 319: C1130–C1140, 2020.
“Sirtuin 3 acts as a negative regulator of autophagy dictating hepatocyte susceptibility to lipotoxicity. ”, Hepatology 66: 936-952, 2017.
“Nrf2 activation-induced hepatic VLDL receptor overexpression in response to oxidative stress contributes to alcoholic liver disease in mice”, Hepatology 59: 1381-92, 2014.